MSM (Methylsulfonylmethane)
Supports muscle & joint comfort, often included in topical creams and balms

TL;DR: MSM is a naturally occurring sulfur compound used topically to support temporary muscle and joint comfort. External use only; follow product guidance.
MSM (methylsulfonylmethane) is a naturally-occurring sulfur compound often used in topical formulations to support joint and muscle comfort. It’s commonly combined with other soothing ingredients for short-term relief.
How MSM Helps
Topically applied MSM can help support soft tissue comfort and may reduce irritation in the area applied. Its combination with other ingredients like menthol or arnica can enhance soothing effects.
Supports joint comfort
May help ease minor muscle or joint soreness.
Topical use
External application only; safe when used as directed.
Often paired with cooling/warming ingredients
Enhances soothing effect in creams and gels.
Gentle on skin
Well-tolerated in low-concentration topical products.
Expert note on MSM
"MSM is a commonly used sulfur compound in topical products that can help support temporary comfort in muscles and joints. It’s most effective when combined with complementary ingredients like menthol or arnica." — Dr. Emily Harris, PharmD (clinical pharmacology, topical analgesics)
Note: This quote refers to the ingredient only, not any specific product.
How to use (safe, practical tips)
- Apply only to intact skin as directed on the product label.
- Avoid eyes, mucous membranes, and broken skin.
- Wash hands after application unless you are treating your hands.
- Discontinue use if irritation occurs and seek medical advice.
FAQ
- What is MSM used for?
- MSM is used topically in creams and gels to help support temporary muscle and joint comfort.
- Is MSM safe for topical use?
- Yes, when used as directed on intact skin. Avoid broken skin, eyes, and mucous membranes.
- Can I combine MSM creams with other products?
- Yes, but follow product instructions and avoid excessive layering of multiple topical treatments.
- How often can I apply MSM creams?
- Follow label instructions. Typically, applications are limited to a few times per day.